Category Archives: HealthCare

Papaya – Medicinal Uses, Interactions, Side Effects, Dosage

Found in tropical countries, the papaya tree is also known as the pawpaw or melon tree. The seeds, leaves, and fruit have all been used in folk medicine. The sap or latex, a milky fluid collected from the mature unripe fruit, is known as crude papain when dried.

Uses and Benefits:

Commercially available papain, a mixture of proteolytic enzymes, is the active ingredient in meat tenderizers; it softens the meat by partially digesting the proteins. Contained in contact lens cleansers, dentifrices, and cosmetics, the enzyme is also used to clarify beer. Papain is available in FDA-approved topical preparations as an enzymatic debridement for necrotic tissue in burns, ulcers, and other wounds. A specific purified fraction, chymopapain, is approved for chemonucleosis (the treatment of herniated intervertebral discs by injection), which has largely fallen out of favor due to allergic and other adverse reactions.

As an herbal dietary supplement, oral papain is most often recommended as a digestive aid (especially with proteinrich meals) and for dyspepsia. Papaya preparations have also been used traditionally for inflammatory disorders, hemorrhoids, intestinal worms, diarrhea, tumors, and respiratory infections. It is used in some cultures to induce abortion and labor, and is employed topically for psoriasis, ringworm, wounds, ulcers, and infections.

Pharmacology:

Crude papain, also called “vegetable pepsin,” is an enzyme mixture from the dried latex of the fruit, and is also found in the leaves and trunk. It is composed of related prote­olytic enzymes: papain, chymopapain A and B, and papaya peptidase. The purified papain enzyme is a thiol protease, obtaining enzymatic activity from the sulfhydryl group of the cysteine It is poorly active in extreme acidic or basic media, can gsted by pepsin, and is poorly absorbed when ingested til; thus, it may have unpredictable activity when exposed to contents. Papain hydrolyzes proteins, small peptidases,

Clinical Trials:

The use of oral papain tablets has been evalutied in several older, controlled clinical trials for post-traumatic in ammation. In double-blind trials of patients undergoing oral or head and neck surgeries, abdominal surgeries, and epiotomies, papaya proteolytic enzyme tablets appeared to Induce postoperative edema, inflammation, or pain when com­pared to placebo. In a randomized, single-blind study in palients undergoing oral surgery, papaya enzyme tablets were more effective than placebo, but less effective than prednisolone 20 rng/day for postsurgical pain and trismus. In a randomized, double-blind trial of college athletes with contusions or re­lated injuries, papaya enzyme tablets produced a better therapeu­tic response and less disability than placebo tablets. The results of several of these studies are questionable, however, because the criteria for the inflammatory signs or pain were subjective, and the study methodologies or results were not well described. In ad­dition, there have been no confirmatory studies in several

Adverse Effects:

There are no significant side effects reported from the clinical studies using oral papaya enzyme tablets. Griping and “intestinal inflammation” from ingestion of the fresh latex has been reported in older accounts.

Side Effects and Interactions:

A papaya extract used as a slimming aid was reported to possibly enhance the effect of warfarin.The patient was admitted for cardiac surgery and found to have an INR of , which declined after withdrawal of both warfarin and the extract. Further details of the case are unknown.

Cautions:

Allergic reactions, including angioedema and anaphylaxis, have been reported with a variety of papain products. Positive skin tests and allergic reactions to papain can be demon­strated in 1 % of individuals with allergies to other substances. Solutions of meat tenderizer used for gastric bezoars, which may not have been sufficiently dilute, have been reported to cause gastric ulcer, esophageal perforation, and hypernatremia. Crude papain orally administered to rats has been reported to be embryotoxic and teratogenic, while no detrimental effects were observed with a purified papain enzyme. Use during pregnancy and lactation is not recommended due to the limited data.

Preparations & Doses:

A typical dose of 1-2 papaya/papain enzyme tablets administered q.i.d. for about 3-7 days was used in the clinical studies to reduce inflammation. Several of these studies used Papase, a product formerly manufactured by Warner-Chilcott Laboratories, which contained 5 mg or 10,000 Warner-Chilcott units (of milk-clotting activity) per tablet. Activity of papain is expressed in many ways, depending on the supplier. Doses of commercial papain products, often recommended as a digestive aid, vary widely between 10 and 1000 mg per day, usually given as 1-4 pills with or after meals. The fresh fruit juice or leaf infusions are also advocated.

Summary Evaluation

Papaya enzymes can hydrolyze protein and are commonly employed as meat tenderizers and wound cleansers. As a dietary supplement, papaya enzymes are used as a digestive aid or to at dyspepsia, but there are no clinical trials to substantiate effects. There is in vitro and animal data to support some of p,Jpaya’s traditional indications, such as for helminthic and fungal tections; these potential properties have also not been evaluted in clinical studies. A number of controlled clinical trials sugust that orally administered papaya enzymes can help to reduce post-traumatic pain and inflammation; however, these older stud (as well as other reported uses) require validation. Papain is poorly active in the gastric contents and may not be appreciably ,absorbed

3 Symptoms That Might Tell You That You Have Colon Cancer

Colon is a muscular, tube-shaped organ located at the lower part of your digestive system. It makes up the main portion of the large intestine. The organ has a key role in helping the body taking in nutrients, water, and minerals. It also helps in removing waste of the body in the form of stool.

Colon cancer is the growth of malignant tumor in the tissue of the colon (in the inner wall of the organ). It is somewhat different from rectal cancer, which is located at the last few inches of the colon (rectum). When left untreated, colon cancer can eventually spread to distant organs all over the body.

Although colon cancer may have numerous symptoms, in the early stages of the disease many suffering from colon cancer experience no symptoms. When the symptoms appear, they tend to vary, depending on the location and size of the cancer in the large intestine. Unfortunately the symptoms of colon cancer are not always obvious. For that reason, it is important for you to learn what the cancer symptoms look and feel like, so you can be aware of the disease for your long-term health.

It is important to note that most of colon cancer cases start as small, noncancerous clumps of cells known as polyps. By time some of these polyps could become cancers. That is why doctors often suggest regular screening tests after the age of 50. This is a way to promote early detection of colon cancer by recognizing polyps before they grow as cancer.

There are 3 symptoms that might tell you that you have colon cancer:

1. Abdominal, bowel and rectal discomfort

Persistent abdominal discomfort, including cramps, gas, pain, constipation, or diarrhea is the commonest symptom of colon cancer. Be careful if you often have a feeling that your bowel does not completely because the cancer can be the cause of the condition. In addition, a change in bowel habits, which includes rectal bleeding and a change in stool consistency, might tell the development colon cancer.

2. Anemia and fatigue

Unexplained iron-deficiency anemia showed by low iron in your red blood cells, or low red blood cell along with extreme tiredness or fatigue is often a strong sign of severe diseases. In fact, fatigue is among the commonest side effects of colon cancer and its treatment. It usually comes on all of a sudden, does not come from exertion or activity, and is not lightened by rest or sleep. Cancer-related fatigue is frequently described as “paralyzing” and may remain after treatment is complete.

In case of cancer, fatigue is likely because the cancerous cells competing for nutrients. Deficiencies of nutrients make the body lacks of energy and feel tired most of the time. Also, lower number or red blood cells leads to severe fatigue due to lower oxygen supply they can carry to the whole part of the body.

3. Loss of appetite leading to unexplained weight loss

If you lose weight due to great loss of appetite while you are not dieting or attempting to lose weight, then you should be careful. That could be a red flag of colon cancer. The discomfort and pain caused by a tumor can bring loss of appetite, which in turn will lead to weight loss. When weight loss happen, it could be an indication that a tumor is generating chemicals that are boosting metabolism of the body.

The loss of appetite related with cancer is also because a tumor growing toward the end of the colon may bring a sense of fullness. It is when body senses that there is something unusual present by the exit. In other words, the body may see the tumor as a stubborn part of waste, so the sufferer acquires that “need to go” sensation, which cannot be relieved as long as the tumor is there.

When most of these symptoms appear, do not hesitate to talk with your doctor. It is time to make an appointment with your doctor immediately to discuss the situation and to arrange for tests so that the root cause of your symptoms can be understood. Remember that you should not be afraid of colon cancer screening and there is nothing to be embarrassed about it. If needed, you can always ask the doctor to schedule for follow-up tests.


Are You a Candidate For Irritable Bowel Syndrome?

Are you a candidate for irritable bowel syndrome? Do you have abdominal pain or cramping? Do you have constipation? Diarrhea? How about vomiting, or fever or headache? How about bloating and water retention? Irritable bowel syndrome is not pleasant for anyone who has it, and many many Americans do suffer from it, in fact more every year.

With a healthy lifestyle that should include moderate exercise and sensible eating habits can help keep the colon cleansed. Two or three good, regular and healthy bowel movements a day are essential to good colon health. Bowtrol Colon Cleanser helps with this. So does good eating. Most Americans eat way too much fast food. Too much sugar, too much fat. Not enough vegetables and fruit. Not enough healthy grains or legumes.

Legumes are beans of all types – green beans, black beans, lima beans, butter beans, brown beans, navy beans, pinto beans, and on and on. Also peanuts are legumes. These are great sources of fiber for better colon cleanliness and better colon health. A one-two punch of better eating habits and Bowtrol Colon Cleanser can make a world of difference in most people. Good colon health and cleanliness can be the difference between a pain free day and a day full of abdominal cramping. It can also be the difference between feeling good and feeling constipated, or bloated or headachy. And remember that good colon health means no diarrhea, an experience few people enjoy.

The reason for good colon health and cleanliness leading to health elsewhere in the body is simple really. The colon is a very large and very complex organ. It contains more nerves than any other organ, except of course for the brain and the spinal column, known as the central nervous system. All other organs in the body are connected to the colon, and all organs in the body work together.

If the colon has problems, these problems spread to other organs and you will feel symptoms of spastic colon, irritable bowel syndrome or another ailment. It only makes good health sense to do what you can to keep your colon cleansed and healthy to keep the rest of your body functioning properly. Bowtrol Colon Cleanser is a great place to start.

Fight Traveller’s Diarrhoea with Travelan

Traveller’s diarrhoea can be an ultimate nuisance to anyone trying to enjoy their trip. The symptoms this condition brings can paralyze you all throughout your travel and strip off all the productivity and happiness in you. Unfortunately, people from developed industrialized nations are those who are more prone to this nemesis, whenever they spend a week or two in a developing country with high-risk of TD causing microorganisms. Generally, this inconvenient condition is due to ingestion of contaminated food or water, the contaminants can be bacteria, viruses or parasites. And the symptoms include: frequent loose bowel movements in 24-hour period, abdominal cramps, abdominal bloating, nausea, vomiting, and even accompanied with mild fever and blood in stools (in some serious cases).

But luckily today, there has been a product clinically proven to reduce the risk of acquiring traveller’s diarrhoea by fighting the most cause of this illness, which is the E. coli Enterotoxigenic (ETEC) infection, called Travelan. In essence, there are approximately 40-75% of all the cases that is due to E. coli ETEC infection (wherein the bacteria can be found in numerous ways), and because of this, the product generally formulated to serve as protection against the main bacterial culprit of this illness is created.

Travelan is manufactured in Australia and is a formulated mixture of antibodies against the common strains of the E. coli ETEC. Its specific ingredient is showed its effectiveness in preventing traveller’s diarrhoea in up to 93% of people exposed to the ecoli infection, as it underwent stringent double-blinded, placebo-controlled trials in Europe and in the United States. Aside from that, the trials have also shown that the few individuals who received Travelan but were still affected by the E. coli had significantly less discomfort and diarrhoea episodes as compared to those who did not receive the product.

So basically, how does Travelan does its wonder? Well, it works by restraining ETEC attachment to the intestinal wall with the antibodies, thereby reducing the incidence of gastrointestinal discomforts. It must be taken in a pill form before every meal (but additional caplets are required when you are snacking between meals or there’s an increased risk of infection depending on the circumstances). In addition, Travelan is made by natural ingredients, as its active ingredient is bovine colostrums (cow’s breast milk), following the immunization of the cow to pertinent strains of ETEC and has anti-microbial properties that will help against other infectious agents as well. And its inactive ingredients are This E. coli ETEC infection risk reducing product made by Australian biotech company Anadis, is not primarily designed as treatment for diarrhoea or traveller’s diarrhoea, and should not be sought when the illness already attacked your system, and should only be taken by individuals not younger than 6 years old. In the event that you are have any condition or allergy that requires medical attention and proper precautionary measures (such as being lactose intolerant), you should consult first your physician before taking Travelan.

Probiotics and the role of Probiotic Supplements Explained

The word ‘probiotic’ actually means ‘for life’. The World Health Organisation define a probiotic as ‘live micro-organism which, when administered in adequate amounts confer health benefits on the host’. Probiotics are friendly bacteria that live in our digestive tract. Probiotics are microorganisms that are similar to the microorganisms that exist naturally in the human stomach. Most are bacteria but some can also be viruses or yeasts – tiny living organisms that can only be seen under a telescope. Probiotics help to keep the natural proportions of good bacteria in the digestive system. They are available in dietary supplements such as capsules, tablets, liquids and powders but can also be found in some foods. Examples of foods containing probiotics include yoghurt, fermented or unfermented milk, miso, tempeh and some juices and soy beverages.

Good bacteria are important for the proper development of the immune system, and for the effective digestion and absorption of food and nutrients into the body. The balance of good bacteria in the stomach can be upset mainly by taking antibiotics and also by the growth of bad bacteria such as disease-causing bacteria, yeasts, fungi and parasites. Though Antibiotics kill bad bacteria, they can also kill good bacteria in the digestive tract. Probiotics counteract antibiotics (hence the name) and can be used to prevent the side effects of taking antibiotics such as gas, cramping or diarrhoea and increase the count of good bacteria in the gut which, as we have already discussed, to to keep a healthy digestive system. They can also be used to ease the symptoms of lactose intolerance. A diet high in processed carbohydrates (particularly sugars and starches) as well as chlorine, fluoride, alcohol and the contraceptive pill can also upset this balance. “Unfriendly” bacteria could be the cause of infectious diarrhoea, irritable bowel syndrome, inflammatory bowel disease, ulcers and many types of chronic stomach inflammation, tooth decay and periodontal disease, vaginal infections, stomach and respiratory infections that children acquire in day care and skin infections.

There are several reasons people are increasingly seeking out probiotics supplements for health reasons. While antibiotics destroys intestinal bacteria, probiotics feed the gut with beneficial bacteria such as the Lactobacillus and Bifidobacterium strains. By supplementing with a probiotic capsule, millions of live bacteria are added into the intestinal wall and can significantly inhibit bad bacteria growth, improve absorption and assimilation of vitamins and minerals, stimulate of the body’s immune system and production of certain vitamins including the important B group vitamins. Many of the readily available probiotics on the market today promote “general well-being,” but scientists are increasingly discovering many more specific benefits from consuming foods with sufficient levels of probiotic bacteria. Probiotics can also be used to:
• Treat diarrhoea
• To prevent and treat infections of the urinary tract or female genital tract
• To treat irritable bowel syndrome or IBS
• To reduce recurrence of bladder cancer
• To shorten the length of intestinal infection
• To prevent and treat pouchitis
• To prevent and manage eczema
• To improve lactose intolerance – The bacterial strain commonly used in yogurt can produce lactase enzymes. Therefore, people with lactose intolerance and children suffering from intestinal infection can usually tolerate yogurt with an active culture.

In addition, new generations of probiotic bacteria are targeted at specific problems or areas of the body. A number of probiotic products are believed to be able to lower cholesterol for example. The ability of probiotic bacteria to support the immune system is very important, especially to the elderly and people suffering from weak.

So Probiotics are good bacteria that exist normally in the digestive system and play an important part in general health and wellbeing. Probiotics can be taken as dietary supplements and these can help with prevention and treatment of a wide range of diseases.